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1

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone

Purro, Silvia A., Farrow, Mark A., Linehan, Jacqueline, Nazari, Tamsin, Thomas, David X., Chen, Zhicheng, Mengel, David, Saito, Takashi, Saido, Takaomi, Rudge, Peter, Brandner, Sebastian, Walsh, Domin

Journal:

Year:

2018

Language:

english

File:

PDF, 4.56 MB

english, 2018

2

Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells

Shirotani, Keiro, Hori, Yuma, Yoshizaki, Ryohei, Higuchi, Eri, Colonna, Marco, Saito, Takashi, Hashimoto, Shoko, Saito, Takashi, Saido, Takaomi C., Iwata, Nobuhisa

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 1.49 MB

english, 2019

3

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

Rice, Heather C., Marcassa, Gabriele, Chrysidou, Iordana, Horré, Katrien, Young-Pearse, Tracy L., Müller, Ulrike C., Saito, Takashi, Saido, Takaomi C., Vassar, Robert, de Wit, Joris, De Strooper, Bart

Journal:

Molecular Neurodegeneration

Year:

2020

Language:

english

File:

PDF, 2.38 MB

english, 2020

4

Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in

Chiasseu, Marius, Fesharaki-Zadeh, Arman, Saito, Takashi, Saido, Takaomi C., Strittmatter, Stephen M.

Journal:

Neurobiology of Disease

Year:

2020

File:

PDF, 7.82 MB

2020

5

Efficacy and safety of combination therapy with elobixibat and colestyramine for non-alcoholic steatohepatitis model mice

Iwaki, Michihiro, Kessoku, Takaomi, Ozaki, Anna, Kobayashi, Takashi, Honda, Yasushi, Ogawa, Yuji, Imajo, Kento, Yoneda, Masato, Saito, Satoru, Nakajima, Atsushi

Journal:

Journal of Hepatology

Year:

2020

File:

PDF, 58 KB

2020

6

Allelic imbalance and mutations of the PTEN gene in ovarian cancer

Misato Saito, Aikou Okamoto, Takashi Kohno, Satoshi Takakura, Hideo Shinozaki, Seiji Isonishi, Takaomi Yasuhara, Tomoaki Yoshimura, Yasuyuki Ohtake, Kazunori Ochiai, Jun Yokota, Tadao Tanaka

Journal:

International Journal of Cancer

Year:

2000

Language:

english

File:

PDF, 127 KB

english, 2000

7

Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers

Satoshi Takakura, Aikou Okamoto, Misato Saito, Takaomi Yasuhara, Hideo Shinozaki, Seiji Isonishi, Tomoaki Yoshimura, Yasuyuki Ohtake, Kazunori Ochiai, Tadao Tanaka

Journal:

Genes, Chromosomes and Cancer

Year:

1999

Language:

english

File:

PDF, 179 KB

english, 1999

8

Activation of the caspase cascade during Stx1-induced apoptosis in Burkitt's lymphoma cells

Nobutaka Kiyokawa, Tetsuya Mori, Tomoko Taguchi, Masahiro Saito, Kenichi Mimori, Toyo Suzuki, Takaomi Sekino, Norihide Sato, Hideki Nakajima, Yohko U. Katagiri, Tae Takeda, Junichiro Fujimoto

Journal:

Journal of Cellular Biochemistry

Year:

2001

Language:

english

File:

PDF, 330 KB

english, 2001

9

Interleukin-1β up-regulates TACE to enhance α-cleavage of APP in neurons: resulting decrease in Aβ production

Yuriko Tachida, Kazuhiro Nakagawa, Takashi Saito, Takaomi C. Saido, Takashi Honda, Yuko Saito, Shigeo Murayama, Tamao Endo, Gaku Sakaguchi, Akira Kato, Shinobu Kitazume, Yasuhiro Hashimoto

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 345 KB

english, 2008

10

Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25

Ko Sato, Seiji Minegishi, Jiro Takano, Florian Plattner, Taro Saito, Akiko Asada, Hiroyuki Kawahara, Nobuhisa Iwata, Takaomi C. Saido, Shin-ichi Hisanaga

Journal:

Journal of Neurochemistry

Year:

2011

Language:

english

File:

PDF, 544 KB

english, 2011

11

A Prospective, Open-Label, Multicenter Study to Assess the Efficacy of Spinal Cord Stimulation and Identify Patients Who Would Benefit

Kazuhide Moriyama, Kazushige Murakawa, Takeshi Uno, Kiyoshige Oseto, Minoru Kawanishi, Yoichi Saito, Takaomi Taira, Masanori Yamauchi

Journal:

Neuromodulation: Technology at the Neural Interface

Year:

2012

Language:

english

File:

PDF, 154 KB

english, 2012

12

Somatostatin regulates brain amyloid β peptide Aβ42 through modulation of proteolytic degradation

Saito, Takashi, Iwata, Nobuhisa, Tsubuki, Satoshi, Takaki, Yoshie, Takano, Jiro, Huang, Shu-Ming, Suemoto, Takahiro, Higuchi, Makoto, Saido, Takaomi C

Journal:

Nature Medicine

Year:

2005

Language:

english

File:

PDF, 786 KB

english, 2005

13

Ligand-independent signaling by overexpressed CD30 drives NF-κB activation in Hodgkin–Reed-Sternberg cells

Horie, Ryouichi, Watanabe, Takuro, Morishita, Yasuyuki, Ito, Kinji, Ishida, Takaomi, Kanegae, Yumi, Saito, Izumu, Higashihara, Masaaki, Mori, Shigeo, Kadin, Marshall E

Journal:

Year:

2002

Language:

english

File:

PDF, 692 KB

english, 2002

14

Expression screening of 17q12–21 amplicon reveals GRB7 as an ERBB2-dependent oncogene

Makoto Saito, Yukiko Kato, Emi Ito, Jiro Fujimoto, Kosuke Ishikawa, Ayano Doi, Kentaro Kumazawa, Atsuka Matsui, Shiori Takebe, Takaomi Ishida, Sakura Azuma, Hiromi Mochizuki, Yoshifumi Kawamura, Yuka

Journal:

Year:

2012

Language:

english

File:

PDF, 934 KB

english, 2012

15

Granulocyte colony-stimulating factor directly affects human monocytes and modulates cytokine secretion

Masahiro Saito, Nobutaka Kiyokawa, Tomoko Taguchi, Kyoko Suzuki, Takaomi Sekino, Kenichi Mimori, Toyo Suzuki, Hideki Nakajima, Yohko U Katagiri, Junya Fujimura, Hiroo Fujita, Koichi Ishimoto, Yuichiro

Journal:

Experimental Hematology

Year:

2002

Language:

english

File:

PDF, 330 KB

english, 2002

16

Single-Step Method for Purification of Shiga Toxin-1 B Subunit Using Receptor-Mediated Affinity Chromatography by Globotriaosylceramide-Conjugated Octyl Sepharose CL-4B

Hideki Nakajima, Yohko U. Katagiri, Nobutaka Kiyokawa, Tomoko Taguchi, Toyo Suzuki, Takaomi Sekino, Kenichi Mimori, Masahiro Saito, Hiroshi Nakao, Tae Takeda, Junichiro Fujimoto

Journal:

Protein Expression and Purification

Year:

2001

Language:

english

File:

PDF, 242 KB

english, 2001

17

Expression in E. coli of finger-domain lacking tissue-type plasminogen activator with high fibrin affinity

Hitoshi Kagitani, Michito Tagawa, Kiyomi Hatanaka, Takaomi Ikari, Akemi Saito, Hiroshi Bando, Kiyotaka Okada, Osamu Matsuo

Journal:

Year:

1985

Language:

english

File:

PDF, 590 KB

english, 1985

18

The calpain—calpastatin system is regulated differently during human neuroblastoma cell differentiation to Schwannian and neuronal cells

Yumiko Saito, Takaomi C. Saido, Kimihiko Sano, Seiichi Kawashima

Journal:

Year:

1994

Language:

english

File:

PDF, 540 KB

english, 1994

19

P1-070: Novel mouse model for Alzheimer’s disease

Takashi Saito, Nobuhisa Iwata, Jiro Takano, Suh-Ming Huang, Takahiro Suemoto, Takaomi C. Saido

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 56 KB

english, 2006

20

P1-113: Accecelerated Aβ plaque formation by low level expression of presenilin-1 with R278I mutation in knock-in mouse

Takahiro Suemoto, Takashi Saito, Jiro Takano, Yukio Matsuba, Naomi Yamazaki, Masaki Nishimura, Nobuhisa Iwata, Takaomi C. Saido

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 56 KB

english, 2008

21

P1-114: The second generation mouse model for Alzheimer disease

Takashi Saito, Nobuhisa Iwata, Jiro Takano, Takahiro Suemoto, Takaomi Saido

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 56 KB

english, 2008

22

Aβ43 is potently amyloidogenic in vivo

Takashi Saito, Takahiro Suemoto, Naomi Mihira, Yukio Matsuba, Jiro Takano, Per Nilsson, Masaki Nishimura, Nobuhisa Iwata, Takaomi C. Saido

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 64 KB

english, 2010

23

APP knock-in mouse: A novel and more relevant model mouse for Alzheimer's disease

Takashi Saito, Yukio Matsuba, Naomi Mihira, Nobuhisa Iwata, Jiro Takano, Per Nilsson, Takaomi Saido

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 138 KB

english, 2012

24

1141 N23K/W27K as developmentally regulated novel neuropeptide genes: I. Molecular cloning and characterization in vitro cell culture system

Yumiko Saito, Kei Maruvama, Yoko Uchida, Takaomi C Saido, Seiichi Kawashima

Journal:

Neuroscience Research

Year:

1996

Language:

english

File:

PDF, 94 KB

english, 1996

25

Aβ Secretion and Plaque Formation Depend on Autophagy

Nilsson, Per, Loganathan, Krishnapriya, Sekiguchi, Misaki, Matsuba, Yukio, Hui, Kelvin, Tsubuki, Satoshi, Tanaka, Motomasa, Iwata, Nobuhisa, Saito, Takashi, Saido, Takaomi C.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.10 MB

english, 2013

26

New Mouse Model of Alzheimer’s

Nilsson, Per, Saito, Takashi, Saido, Takaomi C

Journal:

ACS Chemical Neuroscience

Year:

2014

Language:

english

File:

PDF, 3.17 MB

english, 2014

27

P4-174 Neuropeptides regulate brain amyloid beta levels through a modulation of neprilysin activity

Saito, Takashi, Iwata, Nobuhisa, Takaki, Yoshie, Higuchi, Makoto, Hosoki, Emi, Sekiguchi, Misaki, Matsuba, Yukio, Saido, Takaomi C.

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 160 KB

english, 2004

28

Human prefoldin can inhibit BETA-AMYLOID fibrillation and contribute to formation of non-toxic BETA-AMYLOID aggregates

Sörgjerd, Karin, Zako, Tamotsu, Sakono, Masafumi, Stirling, Peter, Leroux, Michel, Saito, Takashi, Nilsson, Per, Sekiguchi, Misaki, Saido, Takaomi, Maeda, Mizuo

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 55 KB

english, 2012

29

Sa1707 Analysis of Lipotoxicity in Liver Induced by Palmitate In Vivo

Ogawa, Yuji, Honda, Yasushi, Kessoku, Takaomi, Tomeno, Wataru, Imajo, Kento, Mawatari, Hironori, Yoneda, Masato, Kirikoshi, Hiroyuki, Saito, Satoru, Maeda, Shin, Wada, Koichiro, Nakajima, Atsushi

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 141 KB

english, 2014

30

The biological effects of R278I-Presenilin-1 familial mutation on γ-secretase activity and amyloid pathology

Saito, Takashi, Suemoto, Takahiro, Mihira, Naomi, Matsuba, Yukio, Takano, Jiro, Nishimura, Masaki, Iwata, Nobuhisa, Saido, Takaomi C.

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 42 KB

english, 2009

31

Update of novel type and more relevant model mouse for Alzheimer's disease

Saito, Takashi, Saido, Takaomi

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 48 KB

english, 2013

32

Amyloid-beta43 is the potent pathological accelerator for Alzheimer's disease

Saito, Takashi, Saido, Takaomi

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 52 KB

english, 2011

33

Autophagy deficiency increases beta-amyloid pathology and memory impairment in APP transgenic mice

Nilsson, Per, Iwata, Nobuhisa, Sekiguchi, Misaki, Saito, Takashi, Saido, Takaomi

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 50 KB

english, 2012

34

Single APP locus knock-in mouse models of Alzheimer's disease: Distinguishing facts from artifacts

Saido, Takaomi, Saito, Takashi

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 288 KB

english, 2013

35

Neuron specific calcium-induced and proteasome-dependent degradation of Cdk5 activator p35

Sato, Ko, Iwata, Nobuhisa, Takano, Jiro, Saito, Taro, Asada, Akiko, Kawahara, Hiroyuki, Saido, Takaomi, Hisanaga, Shinichi

Journal:

Neuroscience Research

Year:

2010

Language:

english

File:

PDF, 80 KB

english, 2010

36

Single App knock-in mouse models of Alzheimer's disease

Saito, Takashi, Matsuba, Yukio, Mihira, Naomi, Takano, Jiro, Nilsson, Per, Itohara, Shigeyoshi, Iwata, Nobuhisa, Saido, Takaomi C

Journal:

Nature Neuroscience

Year:

2014

Language:

english

File:

PDF, 713 KB

english, 2014

37

Correction to Human Prefoldin Inhibits Amyloid-β (Aβ) Fibrillation and Contributes to Formation of Nontoxic Aβ Aggregates

Sörgjerd, Karin Margareta, Zako, Tamotsu, Sakono, Masafumi, Stirling, Peter C., Leroux, Michel R., Saito, Takashi, Nilsson, Per, Sekimoto, Misaki, Saido, Takaomi C., Maeda, Mizuo

Journal:

Year:

2014

File:

PDF, 312 KB

2014

38

Human Prefoldin Inhibits Amyloid-β (Aβ) Fibrillation and Contributes to Formation of Nontoxic Aβ Aggregates

Sörgjerd, Karin Margareta, Zako, Tamotsu, Sakono, Masafumi, Stirling, Peter C., Leroux, Michel R., Saito, Takashi, Nilsson, Per, Sekimoto, Misaki, Saido, Takaomi C., Maeda, Mizuo

Journal:

Year:

2013

Language:

english

File:

PDF, 1.21 MB

english, 2013

39

Emerging drugs for non-alcoholic steatohepatitis

Tomeno, Wataru, Yoneda, Masato, Imajo, Kento, Ogawa, Yuji, Kessoku, Takaomi, Saito, Satoru, Eguchi, Yuichiro, Nakajima, Atsushi

Journal:

Expert Opinion on Emerging Drugs

Year:

2013

Language:

english

File:

PDF, 351 KB

english, 2013

40

Characterization of a Shiga-Toxin 1-Resistant Stock of Vero Cells

Sekino, Takaomi, Kiyokawa, Nobutaka, Taguchi, Tomoko, Takenouchi, Hisami, Matsui, Jun, Tang, Wei-Ran, Suzuki, Toyo, Nakajima, Hideki, Saito, Masahiro, Ohmi, Kazuhiro, Katagiri, Yohko U., Okita, Hajime

Journal:

Microbiology and Immunology

Year:

2004

Language:

english

File:

PDF, 426 KB

english, 2004

41

Development of a parallel detection and processing system using a multidetector array for wave field restoration in scanning transmission electron microscopy

Taya, Masaki, Matsutani, Takaomi, Ikuta, Takashi, Saito, Hidekazu, Ogai, Keiko, Harada, Yoshihito, Tanaka, Takeo, Takai, Yoshizo

Journal:

Review of Scientific Instruments

Year:

2007

Language:

english

File:

PDF, 1.04 MB

english, 2007

42

Characterization of Monoclonal Antibodies Against Mouse and Rat Platelet Glycoprotein V (CD42d)

Sato, Norihide, Kiyokawa, Nobutaka, Takada, Koji, Itagaki, Mitsuko, Saito, Masahiro, Sekino, Takaomi, Suzuki, Toyo, Taguchi, Tomoko, Mimori, Kenichi, Lanza, François, Fujimoto, Junichiro

Journal:

Year:

2000

Language:

english

File:

PDF, 423 KB

english, 2000

43

Autophagy-Related Protein 7 Deficiency in Amyloid β (Aβ) Precursor Protein Transgenic Mice Decreases Aβ in the Multivesicular Bodies and Induces Aβ Accumulation in the Golgi

Nilsson, Per, Sekiguchi, Misaki, Akagi, Takumi, Izumi, Shinichi, Komori, Toshihisa, Hui, Kelvin, Sörgjerd, Karin, Tanaka, Motomasa, Saito, Takashi, Iwata, Nobuhisa, Saido, Takaomi C.

Journal:

The American Journal of Pathology

Year:

2015

Language:

english

File:

PDF, 2.63 MB

english, 2015

44

Non-alcoholic fatty liver disease comorbid with major depressive disorder: The pathological features and poor therapeutic efficacy

Tomeno, Wataru, Kawashima, Keigo, Yoneda, Masato, Saito, Satoru, Ogawa, Yuji, Honda, Yasushi, Kessoku, Takaomi, Imajo, Kento, Mawatari, Hironori, Fujita, Koji, Saito, Satoru, Hirayasu, Yoshio, Nakajim

Journal:

Journal of Gastroenterology and Hepatology

Year:

2015

Language:

english

File:

PDF, 467 KB

english, 2015

45

Deficiency of iNOS-derived NO accelerates lipid accumulation-independent liver fibrosis in non-alcoholic steatohepatitis mouse model

Nozaki, Yuichi, Fujita, Koji, Wada, Koichiro, Yoneda, Masato, Kessoku, Takaomi, Shinohara, Yoshiyasu, Imajo, Kento, Ogawa, Yuji, Nakamuta, Makoto, Saito, Satoru, Masaki, Naohiko, Nagashima, Yoji, Tera

Journal:

BMC Gastroenterology

Year:

2015

Language:

english

File:

PDF, 2.38 MB

english, 2015

46

ScaleS: an optical clearing palette for biological imaging

Hama, Hiroshi, Hioki, Hiroyuki, Namiki, Kana, Hoshida, Tetsushi, Kurokawa, Hiroshi, Ishidate, Fumiyoshi, Kaneko, Takeshi, Akagi, Takumi, Saito, Takashi, Saido, Takaomi, Miyawaki, Atsushi

Journal:

Nature Neuroscience

Year:

2015

Language:

english

File:

PDF, 6.41 MB

english, 2015

47

GENERATION AND APPLICATION OF SINGLE APP LOCUS KNOCKIN MODEL MICE OF ALZHEIMER'S DISEASE

Saito, Takashi, Matsuba, Yukio, Mihira, Naomi, Saido, Takaomi

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 129 KB

english, 2014

48

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase

Funamoto, Satoru, Sasaki, Toru, Ishihara, Seiko, Nobuhara, Mika, Nakano, Masaki, Watanabe-Takahashi, Miho, Saito, Takashi, Kakuda, Nobuto, Miyasaka, Tomohiro, Nishikawa, Kiyotaka, Saido, Takaomi C., I

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 3.20 MB

english, 2013

49

SCREENING OF PLASMA PROTEIN BIOMARKER CANDIDATES FOR ALZHEIMER'S DISEASE USING A SINGLE APP LOCUS KNOCKIN MICE

Tsukakoshi, Kaori, Saito, Takashi, Saido, Takaomi

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 54 KB

english, 2014

50

MECHANISMS OF AUTOPHAGY-MEDIATED AB SECRETION

Nilsson, Per, Sekiguchi, Misaki, Akagi, Takumi, Izumi, Shinichi, Komori, Toshihisa, Hui, Kelvin, Tanaka, Motomasa, Iwata, Nobuhisa, Saito, Takashi, Saido, Takaomi

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 50 KB

english, 2014